NodThera has changed its name to Rezera and announced a Phase 3 development program. Read Press Release

Leadership

We are led by an experienced team of leaders, entrepreneurs, scientists and clinicians with deep NLRP3, drug development and commercialization expertise.

Geoff McDonough, M.D.
Geoff McDonough, M.D.

Chief Executive Officer

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“I am motivated by the potential to create hundreds of millions of moments for our medicines to change what is possible for patients and their families.”

Geoff McDonough, M.D.

Chief Executive Officer

Geoff brings more than two decades of drug development and commercialization experience. Most recently, he served as President & Chief Executive Officer of Generation Bio, leading it from early startup phase through IPO. Geoff previously served as President & CEO of Sobi, overseeing substantial portfolio expansion and international growth. Earlier in his career, Geoff spent a decade at Genzyme, holding senior roles including President of Genzyme Europe and Senior Vice President & General Manager of the global Lysosomal Storage Diseases business. He trained in internal medicine and pediatrics at Massachusetts General Hospital and Boston Children’s Hospital and earned his M.D. from Harvard Medical School.

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Chris Guiffre, J.D., M.B.A.
Chris Guiffre, J.D., M.B.A.

Chief Financial Officer

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“Like my Rezera teammates, I’m energized by the opportunity to help countless patients with our NLRP3 inhibitors.”

Chris Guiffre, J.D., M.B.A.

Chief Financial Officer

Chris is a veteran biotech leader with more than 25 years of executive experience. He’s served in senior leadership roles in public and private companies, development-stage and commercial companies, and life science and tech companies. Before joining Rezera, he served as interim CFO of Vizgen. Earlier, Chris served as President & COO of Auron Therapeutics, where he also held CFO responsibilities. Prior, Chris was CFO & COO of Pear Therapeutics and, before that, held CBO, CFO, COO, and CEO roles at Cerulean Pharma. During his tenure at Pear and Cerulean, Chris was instrumental in taking both companies public. He also has held senior executive positions at various life science and tech companies, including President & CEO of Alvos Therapeutics, CBO of Hydra Biosciences, Senior Vice President, General Counsel & Secretary at Cubist Pharmaceuticals, and Vice President, General Counsel & Clerk at Renaissance Worldwide. Chris received his M.B.A. from Boston College Carroll School of Management, J.D. from Boston College Law School, and B.S. from Babson College. Chris also teaches strategy at Bentley University.

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Jyothis George, M.D., Ph.D., FRCP, FACE
Jyothis George, M.D., Ph.D., FRCP, FACE

Chief Medical Officer

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“There is only one number that matters in the end – the number of patients served. With ruvonoflast and the broader Rezera pipeline, we have the potential touch millions of lives globally. What could be more energizing?!”

Jyothis George, M.D., Ph.D., FRCP, FACE

Chief Medical Officer

Jyothis brings in depth global leadership expertise in cardiometabolic drug development, regulatory and commercialization strategy.

Prior to Rezera, Jyothis held pivotal executive roles at some of the world's leading pharmaceutical organizations including Amgen, Novo Nordisk and Boehringer Ingelheim. At Amgen he chaired the General Medicine Therapeutic Area, overseeing research, development and delivery across CardioMetabolism, Bone, Neurology, and Nephrology with multiple blockbusters including Evolocumab (Repatha®). At Novo Nordisk he served as Corporate Vice President successfully delivering major regulatory studies for assets including semaglutide (Wegovy®) and launched innovative educational platforms. At Boehringer Ingelheim he served as Global Head of Clinical Development and Medical Affairs (Cardiometabolism) leading the teams for empagliflozin (Jardiance®) and linagliptin (Trajenta®). Working with regulatory and academic experts, Jyothis has pushed the boundaries of streamlined cardiometabolic development, including the incorporation of multiple pragmatic elements into the world’s first GLP-1 outcome trial and the design of EMPA-KIDNEY trial that achieved Fast-Track designation by FDA whilst incorporating low trial costs, and accelerated execution time.

Jyothis has served on the steering committees of six major cardiovascular outcomes trials and has authored over 100 peer-reviewed publications. He is the founder of the CardioMetabolic Health Foundation, a non-profit dedicated to personalizing preventive care and serves as Visiting Professor of Cardiometabolic Medicine at the University of Oxford.
Jyothis holds an MBBS from St. John’s Medical College, in Bangalore India, a Ph.D. in Neuroendocrinology from the University of Edinburgh, and is board certified in Internal Medicine, Endocrinology and Diabetes (UK).

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Alan P. Watt, Ph.D., M.B.A.
Alan P. Watt, Ph.D., M.B.A.

Founder & Chief Scientific Officer

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“I am motivated by turning my two decades of pioneering science on NLRP3 into transformational therapies through entrepreneurial thinking, building exceptional teams, and delivering breakthroughs that improve human health.”

Alan P. Watt, Ph.D., M.B.A.

Founder & Chief Scientific Officer

Alan has over 40 years of experience in Drug Discovery and Development in both the pharmaceutical and biotechnology sectors. His previous roles include serving as interim CSO at Bicycle Therapeutics, and as Chief Operating Officer and EVP of R&D at Trident Pharmaceuticals. Alan formerly led Drug Discovery for Cellzome and Neurology Preclinical Development at GSK before relocating to Philadelphia as VP and Discovery Performance Unit Head at GSK where he established and led inflammation R&D. He also previously led Drug Metabolism and in vivo Pharmacology at Merck & Co’s Neuroscience Research Centre. Alan holds a Bachelor of Science in Chemistry from the University of Southampton, a Ph.D. in Drug Metabolism from the University of Hertfordshire and an M.B.A. from the Open Business School. He is Chair of Babraham Institute Enterprise, is visiting lecturer at ESCP Business School and has over 60 peer-reviewed scientific publications.

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Nick Clarke, Ph.D.
Nick Clarke, Ph.D.

Chief Development Officer

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“Having taken multiple Rezera molecules into clinical development, I am delighted to take ruvonoflast into Phase 3 clinical trials. “

Nick Clarke, Ph.D.

Chief Development Officer

Nick is an expert in development of drug candidates through preclinical and clinical phases. Prior to joining Rezera, he spent over 20 years at Pfizer in the UK and US, where he led successful drug development projects across a variety of therapeutic areas, including allergy, respiratory, inflammation and rare disease. Under his leadership, these projects progressed through early preclinical experimentation and candidate selection to initial clinical studies in volunteers and Phase 2a and Phase 2b trials in patients. Nick received his Bachelor of Science in pharmacology from the University of Portsmouth and his Ph.D. in anatomical neuropharmacology from the University of Oxford.

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Karolina Chwalek, Ph.D., M.B.A.
Karolina Chwalek, Ph.D., M.B.A.

VP, Business Development

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Karolina Chwalek, Ph.D., M.B.A.

VP, Business Development

Karolina leads business development, investor relations, and corporate communications. Prior to Rezera, she was Vice President of Business Development at Voloridge Health, where she led strategic investments, and previously held senior corporate development and strategy roles at Frequency Therapeutics. Earlier in her career, she was a founding team member at Life Biosciences and co-founded a biotechnology startup, Spotlight Biosciences, contributing to the financing and development of a portfolio of biomedical ventures.

She has served on the boards of Molecular You, ONVY, and SiPhox Health. Her scientific background spans research roles at Harvard Medical School, Tufts University, the Max Planck Institute for Cell Biology and Genetics, and the Leibniz Institute for Polymer Research, resulting in multiple peer-reviewed publications.

Karolina holds a M.Sc. in Molecular Biology from Nicolaus Copernicus University in Toruń, Ph.D. in Regenerative Medicine from Technische Universität Dresden, an M.B.A. from Quantic School of Business and Technology.

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David Harrison, MChem CChem FRSC
David Harrison, MChem CChem FRSC

VP, Medicinal Chemistry

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David Harrison, MChem CChem FRSC

VP, Medicinal Chemistry

David joined Rezera during its seed-funded stage and is an inventor of all four clinical molecules. David leads the medicinal chemistry function, working collaboratively with biology, DMPK and computational chemistry colleagues to design and optimize molecules towards candidate selection. He is the first author of several publications on NLRP3 inhibitors and has given invited talks on this subject at various international conferences. Prior to Rezera, he worked as a medicinal chemist at leading pharmaceutical companies, including Novartis, GSK and Takeda.

David holds a MChem in Chemistry from the University of Southampton. He has been awarded Chartered Chemist status and admitted as a Fellow of the Royal Society of Chemistry.

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Nicola Lindsay, BSc
Nicola Lindsay, BSc

VP, Clinical Program & Portfolio Management

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Nicola Lindsay, BSc

VP, Clinical Program & Portfolio Management

Nicola leads Clinical Program and Portfolio Management ensuring the Portfolio can progress within time, budget and scope considerations, delivering each molecule's full potential.

Prior to Rezera, she was Vice President Program & Portfolio Management at Amphista Therapeutics, a biotech where she was able to lead the first successful IND submission, alongside supporting the set up of a clinical team and associated requirements to enable the Company’s First, First in Human study, within Oncology. Nicola has previously also worked in several pharmaceutical companies (Pfizer, GSK and AZ) where she has a proven track record of developing molecules within a range of pre-clinical and clinical phases.

Nicola holds a Project Management Professional certification from the Project Management Institute since 2019. Nicola also has a Bachelor of Sciences honors degree from The University of Paisley.

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Julie-Ann Penton, BSc Ph.D.
Julie-Ann Penton, BSc Ph.D.

VP, Technical Operations

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Julie-Ann Penton, BSc Ph.D.

VP, Technical Operations

Julie-Ann leads Technical Operations at Rezera, where she is responsible for the company's Chemistry, Manufacturing and Controls (CMC) strategy, technical development, manufacturing and supply across the product portfolio. She provides strategic leadership for drug substance and drug product development, analytical sciences, clinical manufacturing, regulatory CMC activities and external manufacturing partnerships, supporting the progression of Rezera’s small-molecule programmes through clinical development to commercialization.

With more than 30 years of pharmaceutical development experience, Julie-Ann has held leadership roles across biotechnology and specialty pharmaceutical companies, including Therakind, Vectura and Innovata. She also founded Penton Consultancy Services, providing strategic CMC and technical operations leadership to biotechnology and pharmaceutical companies, including supporting Phase 2 to Phase 3 transitions, regulatory submissions and commercial readiness.

Julie-Ann holds a B.Sc. in Pharmacy from Aston University and a Ph.D. in Pharmaceutics from the University of Manchester. She completed her pharmacy pre-registration training at Pfizer Central Research in Sandwich, Kent.

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Valérie Reader, BSc MSc
Valérie Reader, BSc MSc

VP, Scientific Operations

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Valérie Reader, BSc MSc

VP, Scientific Operations

Valérie leads drug substance development with responsibility spanning late-stage development, process optimization, and manufacturing strategy. She is a medicinal chemist with more than 35 years of experience in the pharmaceutical and biotechnology industry, driven by a passion for connecting scientific innovation with the people and organizations that can maximize its impact and ultimately improve patients' lives.

Her career began at SmithKline Beecham in the United States before moving to the UK, where she held roles across several biotechnology companies, contributing to the discovery and development of innovative medicines. In 2016, she joined Rezera at its inception, helping to build the company from the ground up.

Throughout her career, she has established and managed an extensive network of scientific collaborators and strategic partners, ensuring that the right expertise is brought together to meet evolving business and scientific needs. As Rezera has grown, her role has evolved beyond discovery research to overseeing the Chemistry, Manufacturing and Controls (CMC) progression of the company's therapeutic assets, guiding programs from late discovery through to clinical trials.

Valérie obtained a Diplôme d'études approfondies and a Maitrise de Chimie from the Université d’Orsay (Paris XI).

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Pete Thornton, BSc, Ph.D.
Pete Thornton, BSc, Ph.D.

VP, Translational Science

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Pete Thornton, BSc, Ph.D.

VP, Translational Science

Pete Thornton leads Translational Science, offering decades of senior scientific leadership in the biopharmaceutical sector. He possesses deep and proven expertise in driving drug discovery and development programs from inception through to development, drawing on an impressive professional background at MedImmune and AstraZeneca.

Throughout his career, Pete has cultivated a wealth of experience spanning the entire R&D continuum. His expertise is particularly concentrated within the neuroinflammation, pain and metabolic therapeutic areas, where he has demonstrated a proven track record of leading both small molecule and biologic (large molecule) programs. His comprehensive operational and strategic insight spans the critical milestones of drug development, successfully guiding assets from initial target validation and lead optimization through to human clinical trials.

An accomplished academic and thought leader, Pete holds a B.Sc. in Pharmacology from the University of Bristol and a Ph.D. in Neuroinflammation from the University of Manchester. He has published extensively in top-tier peer-reviewed journals on the topics of neuroinflammation and metabolism, with a specialized focus on the role of glial and cerebrovascular inflammatory mechanisms in disease pathogenesis.

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Shawna-Gay White, J.D., M.A.
Shawna-Gay White, J.D., M.A.

VP, Deputy General Counsel

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Shawna-Gay White, J.D., M.A.

VP, Deputy General Counsel

Shawna-Gay oversees the company’s legal affairs and provides strategic, legal and business guidance to the board and executive leadership across a broad range of matters.

With more than 15 years of experience in the life sciences and technology sectors, she is recognized for combining practical business judgment with legal expertise to help companies navigate complex challenges, manage risk, and achieve their strategic objectives. Prior to Rezera, she served as Vice President, Corporate & Securities Law and Corporate Secretary at Generation Bio, where she led legal support for securities compliance, governance, risk management, and employment matters. Earlier in her career, she held progressively senior roles at EchoStar Corporation, developing a wide-ranging corporate practice spanning transactional, governance, and operational matters.

Shawna-Gay received her J.D. and M.A. in Public Policy from Stanford University and A.B. from Harvard University.

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Don Nicholson, Ph.D.

Chairman

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Don Nicholson, Ph.D.

Chairman

Don most recently served as CEO at Nimbus Therapeutics. He previously spent 25 years at Merck, where he held strategic, leadership and operational roles across diverse therapeutic areas including inflammation, immunology and neurosciences. Don began his career at Merck Frosst in Montreal as a senior research biologist and held positions of increasing responsibility, including vice president and site head of the Merck Neurosciences Research site in San Diego, vice president of immunology and infectious diseases, and vice president and worldwide discovery head for bone, respiratory, immunology and endocrine disorders. Don has co-authored more than 150 publications in peer-reviewed scientific and medical journals and is internationally recognized for his contributions. He received his doctorate in biochemistry from the University of Western Ontario and trained as a Medical Research Council postdoctoral fellow at the University of Munich in Germany. He is the recipient of multiple academic and professional honors. Don is also a member of the board of directors of Kymera Therapeutics and Generation Bio, and serves as board chair for Jnana Therapeutics, Disc Medicine and Muna Therapeutics.

Geoff McDonough, M.D.

Chief Executive Officer

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Geoff McDonough, M.D.

Chief Executive Officer

Geoff brings more than two decades of drug development and commercialization experience. Most recently, he served as President & Chief Executive Officer of Generation Bio, leading it from early startup phase through IPO. Geoff previously served as President & CEO of Sobi, overseeing substantial portfolio expansion and international growth. Earlier in his career, Geoff spent a decade at Genzyme, holding senior roles including President of Genzyme Europe and Senior Vice President & General Manager of the global Lysosomal Storage Diseases business. He trained in internal medicine and pediatrics at Massachusetts General Hospital and Boston Children’s Hospital and earned his M.D. from Harvard Medical School.

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Elisabeth Bjork, Ph.D.

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Elisabeth Bjork, Ph.D.

Elisabeth has been a member of Rezera’s Board of Directors since 2025; she most recently served as Senior Vice President (SVP), Head of Obesity franchise at AstraZeneca. Elisabeth has more than 30 years of experience from clinical practice, academic research and drug development, including various leadership roles at AstraZeneca for more than 20 years. She has worked strategically and operationally covering the entire clinical development process, large-scale outcomes programs, major global filings and health authority interactions, as well as commercial strategy and implementation. Elisabeth is an endocrinologist by training and an Associate Professor of Medicine at Uppsala University, Sweden. She holds an M.D. from the Karolinska Institute and a Ph.D. in Endocrinology from Uppsala University.

Alex Pasteur, Ph.D.

F-Prime Capital

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Alex Pasteur, Ph.D.

F-Prime Capital

Alex is a Partner with F-Prime Capital. With over 20 years investing experience, Alex’s investments span therapeutics and healthcare IT, including Nodthera Inc., Tenpoint Therapeutics Ltd, Oviva AG, Owkin Inc., Genomics PLC, Castor (Ciwit BV), Pulmocide Ltd, Orchard Therapeutics, Acacia Pharma, and Adaptimmune Therapeutics. Prior to joining F-Prime in 2012, Alex worked at MVM Life Science Partners LLP in the USA and Europe. Alex earned a M.A. in Natural Sciences from Cambridge University and a Ph.D. in Chemistry from Cambridge University.

Kevin Raidy

Blue Owl Capital

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Kevin Raidy

Blue Owl Capital

Kevin is a Managing Director at Blue Owl and the Head of Healthcare Opportunities. In this role, he oversees all private and public investment activity related to Healthcare Opportunities and sits on the Fund’s Investment Committee.Previously Kevin was a founder and Managing Partner of Cowen Healthcare Investments, the predecessor to Blue Owl Healthcare Opportunities. Prior to his role at Cowen Healthcare Investments, Kevin was Cowen’s Head of Investment Banking and prior to that he was Co-Head of Cowen’s Equity Capital Markets Group. Before that Kevin was a Managing Director at Ramius LLC where he was responsible for direct investments and convertible bonds. Kevin’s sell side experience includes ten years at Shipley Raidy Capital Partners, a boutique investment banking firm which he co-founded. Prior to founding Shipley Raidy, Kevin was an associate at Philadelphia First Group. He started his career at Cantor Fitzgerald before moving to Merrill Lynch as an analyst in the municipal finance group. Kevin received a BS in Economics with a concentration in Finance from the Wharton School of the University of Pennsylvania.

Henrijette Richter, Ph.D.

Sofinnova Partners

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Henrijette Richter, Ph.D.

Sofinnova Partners

Henrijette is a Managing Partner at Sofinnova Partners and an active member of the Capital Funds team, the firm’s flagship fund dedicated to early-stage biotechs and medtechs. In addition to being an active member of Nodthera’s Board of Directors, her investments and other board roles include Mozart Therapeutics, Muna Therapeutics, Nitrase Therapeutics, Twentyeight-Seven Therapeutics, Asceneuron, Delinia (sold to Celgene), and iOmx Therapeutics. Prior to joining Sofinnova in 2014, Henrijette was part of the team that founded Novo Seeds in 2007, and as an Investment Director, she was instrumental in the creation, financing and building of companies such as Orphazyme (ORPHA.CO; ORPH), Avilex Pharma, EpiTherapeutics (sold to Gilead), and Lysogene. Henrijette holds a combined Ph.D. and Industrial Scientist degree in Molecular Biology from the University of Copenhagen and Novo Nordisk A/S. She did her postdoctoral fellowship at the MIT Center for Cancer Research in Massachusetts.

Jim Trenkie, Ph.D.

Novo Ventures

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Jim Trenkie, Ph.D.

Novo Ventures

Jim joined Novo Ventures (US) Inc. as a Partner in May 2022. Jim brings a background in R&D, commercialization, and early stage biotech investing and transactions. Prior to joining Novo, Jim was Head of Investments at Sanofi Ventures in Cambridge, MA, where he was responsible for a team making investments into private US-based therapeutics life science companies. Prior to Sanofi, Jim was Vice President of Investments with Pivotal bioVenture Partners in San Francisco. Jim began his career with Gilead Sciences where he held positions of increasing responsibility in medicinal chemistry, project and portfolio management, and commercial strategy, largely focused on hepatitis C and other liver diseases. Jim completed a B.S. in Honors Chemistry at University of Michigan, a Ph.D. in Organic Chemistry at Massachusetts Institute of Technology and holds an M.B.A. from University of California Berkeley, Haas School of Business.

Scott Rocklage, Ph.D.

5AM Partners

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Scott Rocklage, Ph.D.

5AM Partners

Scott joined 5AM Ventures in 2003 as a Venture Partner, became a Managing Partner in 2004 and transitioned to Founding Partner in 2017. Scott has over three decades of healthcare management experience with strategic leadership responsibilities that led to FDA approval of three U.S. New Drug Applications (Omniscan™, Teslascan® and Cubicin®). He has served as Chairman and CEO of Cubist Pharmaceuticals, President and CEO of Nycomed Salutar and has also held R&D positions at Salutar and Catalytica. Scott formerly served as Board Chairman of Relypsa (acquired by Vifor Pharma), Novira (acquired by J&J), Aprea, Cidara, Albamunity and Halio. He currently serves as Board Chairman of Expansion and is a Board member at NodThera and Nouscom. He was formerly Executive Chairman of Ilypsa (acquired by Amgen), Miikana (acquired by EntreMed) and Semprus (acquired by Teleflex). Scott received his B.S. in Chemistry from the University of California, Berkeley and his Ph.D. in Chemistry from MIT where he conducted research in the laboratory of Richard R. Schrock (Nobel Prize in Chemistry in 2005). He is an inventor or co-inventor of over 35 U.S. patents and has produced more than 100 peer-reviewed publications.

5AM Ventures
Blue Owl
Epidarex Capital
F Prime
Novo Holdings
Sanofi Ventures
Sofinnova Partners